G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to girkG proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative diseases such as Alzheimer’s dementia and Parkinson’s disease.
G Protein-Coupled Inwardly-Rectifying Pgirkotassium Channels (GIRK channels) are channels found in the brain that play a crucial role in the inhibitory effects of neurotransmitters.
The G protgirkein-coupled inwardly rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand -stimulated G protein-coupled receptors (GPCRs). [1][2] GPCRs in turn release activated G-protein ...
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